OS4 is hobby OS, so no Far Cry 3 or Crysis 3. Games are open source ports or SDL. Word prosessing is oK, I don't know spreadsheet or databsing. I belive it can't run video toaster, but rendering is possibl with blender and old 68k render programs, like lightwave, Real 3D etc.
AmigaOne x1000 and Sam 460 has a problem, there is no currently fully supportd graphics card for them PCIe, wich means no 3d support, no overlay support, so you can watc DVDs but ther are limitations. Digital music is ok, there is tunet for internet radios etc. and several ways to listen mp3s
Basic tasks like internet browsin, etc works very well
Currently best support is for Radeon 9XXX cards, like Radeon 9250
It is possible to install linux to AmigaOne and run it with Amiga OS4