No, because the BYTE value of $78563412 is $12 - just as it would be with a software only op-code interpreter.
If you're writing to cachable area then write caching means it might not even make it onto the bus before the value gets read back, even if it does make it into ram then the cpu has already cached the value that it wrote so it won't bother to read it again. There is no way you could write a little endian 68000 emulator running on a modern processor and then use an fpga to convert it to big endian.
You could convert a 286 processor to big endian, or a 68000 to little endian because it has no caches and reads/writes go straight to the bus. Or you could turn the caches off.
I don't believe you've thought it through at all.
That's what I was thinking also. Anything that would break is already broken with existing accelerators.
Or even running on an A3000/A4000/A1200. Most A500/A2000 accelerators had a fall back to the built in 68000, so you could argue that this would be nice for anything for those. But an A3000/A4000/A1200 doesn't even have the chance of running software that required an A500 timing.
WHDLOAD already has patches for a lot of those. Or you can find patched versions of some demos.
There might be new bugs introduced by running a 68000 at 200mhz that never showed up before, but I'm not sure how much I care about that. If it's an important enough piece of software then someone will write a patch for it.