Since it is Mini-ITX there are so many cool cases to chose from, I would have chosed the smallest possible case with a laptop DVD and 2.5" HD.
Even though the mobo is tiny it is still tall on some places, it can be difficult to mount it in a A500/A1200 case (I tried that with a previous Mini-ITX mobo). But if a all new custom solution appears yes.
I agree that the case above is ugly, in the PC world, nobody seems to know how to design a good looking case except Apple.