You would need a driver for it, if using something like a GoldenGate2 bridgecard, such driver does not exist. ISTR someone was writing a GG2 driver for the Adaptec 1540 ISA card, but it never surfaced.
Oh, and the GG2 didn't support ISA DMA mode, which made life even slower. And thats before you consider that getting 16bit cards to work could be tricky...