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Offline KarlosTopic starter

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Prebiotic chemistry and origins of life (continued)...
« on: December 15, 2004, 02:08:48 PM »
For fluffy :-)

Rather than continue hijacking the_leander's threads, I figured it would be rather better to create one...

So, going back to this one, lets take a stock check. Existing evolutionary models explain the diversification and origin of new species of entire organisms relatively well. I have no issue with this at all.

For me, as we have discussed, the problem is the biochemical level. Prebiotic chemistry is a fascinating area that I studied intensely for a while. Foregoing for a moment the argument about how it all started, let's think about it for a moment.

It seems to me that there has been no significant (bio)chemical evolution for a very, very long time. What do I mean by this? Well, there may be small improvements in cell chemistry here and there, but by and large your human internal cellular machinary is not far in advance of any other eukaryotic organism - just look at yeast and you will find the same chemistry going on. Eukaryotes are themselves a step up from prokaryotes that have new biochemical pathways added on top of the prokaryotic set but do not significantly change those they inherited.

If you look at the most primitive forms of viral life you can find (and arguably they are not even really living), you  find that they still use the same chemistry. They still use at least RNA to store their compositional make up and they use protein casings etc.

It seems therefore, that the biochemical complexity known today is largely unchanged in every organism known. Were still using the same nucleic acids, proteins, electron transport chains, photosynthetic systems since pa(ramecium) fell of the bus (to paraphrase X-Ray). Of course there are better examples of some metabolic systems, but fundamentally the chemistry has not changed.

This is one reason I don't think that existing evolutionary theory (as it applies to biology) applies to the chemistry that enables the biology to exist.

If we consider that biological evolution is taking place all around us, why do we not observe the same in chemistry? Once you have a self replicating, sustainable chemical system there is no reason to assume it would be completely replaced by a more efficient one, just as bacteria still exist in profusion, despite being biologically usurped by more sophisticated organisms competing for the same resources.

If the existing evolutionary models apply to chemistry, why are there no pre - nucleic acid / protein chemstry based organisms known? Just because the latter may be more efficient, the former system(s) capable of self replication should still exist. Yet none do.

So, the biochemistry we know - that is nucleic acid / protiens / sugars / redox / electron transport / photosynthesis - has been around relatively unchanged since life began, despite the vast changes in the biology it has enabled. In fact, the only variations we see are in how that chemisrty sources the energy it needs in order to drive itself (be it photosynthesis, iron-sulfur, carboyhdrate oxidation etc).

There is no evidence that the chemistry itself was ever any less sophisticated; there are no rival self-replicating chemistries known, no evidence any have ever existed and no evidence that the existing biochemistry has changed significantly or is changing. In short there is no tangible  evidence of "chemical evolution".

So the questions remain. Where did the present chemistry come from and how did it establish itself so quickly given that it appears to have moved so little since? After all, it is generally believed the first single celled organisms powered by this chemistry were happily replicating wihin 200 million years of conditions being favourable.

There are many other reasons why I don't believe the existing evolutionary paragdims (as applied to biology) apply to the underlying chemistry, the above are just a few.

In my opinion, there is so much more to discover - sticking to creationalism or darwinism are not going to get us far.


If the_leander is reading this, feel free to hijack - it is only fair :-D
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Offline PMC

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #1 on: December 15, 2004, 02:22:11 PM »
Quote

Karlos wrote:
 eukaryotic organism -


Until now I thought that was the name of a Finnish metal band.

Quote


It seems therefore, that the biochemical complexity known today is largely unchanged in every organism known. Were still using the same nucleic acids, proteins, electron transport chains, photosynthetic systems since pa(ramecium) fell of the bus (to paraphrase X-Ray). Of course there are better examples of some metabolic systems, but fundamentally the chemistry has not changed.


The upshot is "if it ain't broke then don't fix it".  Despite the obvious progression of evolution over however many billion years, basic fundamentals barely change.  However far you go back, the realisation that what evolution created was not necessarily "primitive" but a response to an environmental challenge.  The Crocodile hasn't changed much in 120 million years, but it's purpose has remained the same, the Ceolocanth has remained the same creature for 200 million years.  

The primate family can trace it's direct ancestry back 80 million years, mammals predate Sauropods and many species of plant are fundamentally unchanged since before the great extinction 65 million years ago.
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Offline KarlosTopic starter

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #2 on: December 15, 2004, 02:39:32 PM »
I know what you are saying, but I think you are missing my point. There is no available evidence to support the notion that the fundamental biochemistry we know of is evolved from anything less primitive - no matter how far back you go, find the same chemistry. There are no cousins, no other evolutionary offshoots, rivals or specialisations that you might expect to find given the way biological evolution appears to have worked.
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Offline bjjones37

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #3 on: December 15, 2004, 02:57:12 PM »
Quote

Karlos wrote:
I know what you are saying, but I think you are missing my point. There is no available evidence to support the notion that the fundamental biochemistry we know of is evolved from anything less primitive - no matter how far back you go, find the same chemistry. There are no cousins, no other evolutionary offshoots, rivals or specialisations that you might expect to find given the way biological evolution appears to have worked.

What a very interesting statement.
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Offline KennyR

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #4 on: December 15, 2004, 02:58:57 PM »
The amino acid code for the simplest self-replicating molecule than can be thought up is Lee's peptide:

RMKQLEEKVYELLSKVACLEYEVARLKKLVGE

Where each letter corresponds to an amino acid. This is the best that theorists can come up with, and it's pretty simple. It is probably impossible to find simpler self-replicating molecules.

So supposing you had a system that allowed peptides to form and join up, which no naturally existing non-bioligical system today allows (because water and oxygen in excess don't favour peptide bonding - ask Karlos).

There are about 2000000000000000000000000000000000 different ways of forming a polypeptide that are exactly 32 long like the one above. Only one way will make that self-replicator.

Even if the earth was 20 times the size and covered by one huge "warm pond", this would not happen by chance. Clearly, pre-biotic chemistry has a long way to go.

The answer of course is probably that it's not by chance, and that some symmetry inhereted from the quantum fluff that makes up the foundation of the universe favours life. In fact, there's no doubting it: it does, or we wouldn't exist.

This in itself does not disprove the engineering of a higher power. Some would even say it proved it.
 

Offline bjjones37

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #5 on: December 15, 2004, 03:32:42 PM »
I thought these might be interesting to this thread.

http://www.answersingenesis.org/creation/v19/i4/blood.asp
http://www.talkorigins.org/faqs/dinosaur/blood.html
http://www.naturalselection.0catch.com/Files/fossilrecord.html

They all three basically refer to the discovery of red blood cells within a partially fossilized T-Rex bone.  The first seeks to support it, the second seeks to disprove it, and the third is sort of neutral and just talks about it. What is interesting to me though is that none of the three denies that there is unfossilized bone tissue there.  This tissue could give us a better understanding of the biochemical makeup of these extinct reptiles, especially if the DNA strands in the nuclei are intact.  I wonder if these dinosaurs have been extinct for as long as it has been estimated.
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Offline KarlosTopic starter

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #6 on: December 15, 2004, 03:37:24 PM »
Quote

KennyR wrote:

RMKQLEEKVYELLSKVACLEYEVARLKKLVGE


What does that come out to as a triple word score in scrabble?

Seriously, Kenny is right - prebiotic earth, with its reducing atmosphere, abundence of base materials and energy etc. possibly did favour spontanous peptide formation - soemthing which today only works thanks to the biochemical machinery that performs it - but would still be extremely lucky to even get as far as Lees peptide within the lifespan of the planet today, let alone 3.5 billion years ago. You still have to arrive at RNA as a better source of self replication and cataltytic activity (there are known RNA strands that perform various self-splicing and self-assembly within biochemistry), let alone moving towards the dual protein / nucleic acid system we have today. Yet all this must have been in place within about 200 million years of the raw chemical precursors needed for their assembly.
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Offline bloodline

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #7 on: December 15, 2004, 03:45:57 PM »
While I have a long and complex answer for you Karlos, one phrase that keeps repeating over and over in my mind is: "The Laws of Physics haven't changed in 3.5 billion years!"

By the way, you must be forgetting your crystal chemistry (or maybe you have sucessfully purged from your mind as I spend every waking hour trying to)... but Crystals are a classic example of a self replicating system and totally inorganic too!

Offline KennyR

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #8 on: December 15, 2004, 03:47:38 PM »
Quote
bjjones wrote:
They all three basically refer to the discovery of red blood cells within a partially fossilized T-Rex bone. The first seeks to support it, the second seeks to disprove it, and the third is sort of neutral and just talks about it. What is interesting to me though is that none of the three denies that there is unfossilized bone tissue there. This tissue could give us a better understanding of the biochemical makeup of these extinct reptiles, especially if the DNA strands in the nuclei are intact. I wonder if these dinosaurs have been extinct for as long as it has been estimated.


One problem - red blood cells have no nuclei and no DNA! :-(
 

Offline cecilia

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #9 on: December 15, 2004, 03:50:58 PM »
Quote

Karlos wrote:
Quote

KennyR wrote:

RMKQLEEKVYELLSKVACLEYEVARLKKLVGE


What does that come out to as a triple word score in scrabble?
i thought it was welsh.


 :-D
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Offline bjjones37

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #10 on: December 15, 2004, 03:52:08 PM »
Quote

KennyR wrote:

One problem - red blood cells have no nuclei and no DNA! :-(


I was not referring to the red blood cells, but the bone tissue itself. Bone cells must have a nuclei in order to be self replicating.  Of course the red blood cells do not replicate but are produced by the marrow. The existence of the red blood cells is under debate.  But if some bone cells are intact...
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Offline bloodline

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #11 on: December 15, 2004, 04:07:35 PM »
Quote

cecilia wrote:
Quote

Karlos wrote:
Quote

KennyR wrote:

RMKQLEEKVYELLSKVACLEYEVARLKKLVGE


What does that come out to as a triple word score in scrabble?
i thought it was welsh.


 :-D


Actually it's a small village a short way from Abergavenny.

Offline KarlosTopic starter

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #12 on: December 15, 2004, 04:16:12 PM »
Quote

bloodline wrote:

By the way, you must be forgetting your crystal chemistry (or maybe you have sucessfully purged from your mind as I spend every waking hour trying to)... but Crystals are a classic example of a self replicating system and totally inorganic too!


No, I didnt forget at all. But I don't regard crystal self assembly as comparable to biochemical where different systems are involved in a complex symbiotic process - eg proteins replicate DNA and transcribe it, but the DNA stores the information required to assemble the proteins.

Symmetry (dictated by ionic/covalent concerns) and close packing hardly compare to the above.
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Offline bloodline

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #13 on: December 15, 2004, 04:21:18 PM »
Quote

Karlos wrote:
Quote

bloodline wrote:

By the way, you must be forgetting your crystal chemistry (or maybe you have sucessfully purged from your mind as I spend every waking hour trying to)... but Crystals are a classic example of a self replicating system and totally inorganic too!


No, I didnt forget at all. But I don't regard crystal self assembly as comparable to biochemical where different systems are involved in a complex symbiotic process - eg proteins replicate DNA and transcribe it, but the DNA stores the information required to assemble the proteins.

Symmetry (dictated by ionic/covalent concerns) and close packing hardly compare to the above.


I personally see no difference, simply the scale of the problem, nothing more nothing less.

I also don't see why life didn't "hitch a ride" on a Crystaline scafholding before the complex RNA/DNA structures developed.

Offline KarlosTopic starter

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Re: Prebiotic chemistry and origins of life (continued)...
« Reply #14 on: December 15, 2004, 04:37:28 PM »
Quote

bloodline wrote:

I also don't see why life didn't "hitch a ride" on a Crystaline scafholding before the complex RNA/DNA structures developed.


For one, there are no vestigial remmenants of this. Whilst it is true that many complex clays can interact with biological systems and in some cases are used, it seems to be the case that biology has found a use for the clays *since* reaching it's present level of complexity and not during its origin.
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