@Paul_Gadd:
Just had a look at that link on Genesis control pads.
I see why they might damage Amiga ports.
It seems that unlike Megadrive pads, the Genesis ones have a select
button, which is connected to pin 7, the 5V output on Amiga.
Assuming the select button is a pull to ground input, pushing the
button would cause a short circuit from 5V to ground.
From memory that pin is protected by a series resistor, so probably
the worst thing is you'll burn out the resistor by holding down
select. Probably best to disconnect the select button in that case.