To be honest, I have noticed very little to no difference with all of the different patches and libs, so I am not the best person to ask. But I am waiting for someone who is up on the subject to comment.
I saw benchmarks comparing Cyberpatcher, Oxypatcher and HSMathLibs, and CyberPatcher seemed to win the most, Oxy improved from default on a few tests, and HSMathLibs did NOTHING. The only time it did win was by huge margins, on the tests included with the libs themselves, which is why I don't trust them.
But as I said, I think we better wait for an expert to tell us the truth...