Been running it on all my Amiga's for years. No "odd issues or instability".
Just to give you an idea. Some versions of TurboPrint allocate their memory for staying resident themselves by walking the exec memory chunk list, and essentially performing an AllocMem(...,MEMF_PUBLIC|MEMF_REVERSE) by themselves. One could clearly say "don't do this", but given that MEMF_REVERSE was broken on at least some versions of exec, TurboPrint didn't have much of a choice, really.
Now, with the patch installed, exec memory is no longer a singly-linked list of chunks, but a smarter structure (I believe it is a "buddy allocator"). This is in general a good thing, and certainly a smarter structure, but it necessarily breaks at least some versions of TurboPrint.
The exec memory chain is unfortunately documented (it better should not have been, but too late), hence it is part of the interface exec provides, and hence every replacement has to satisfy this interface as well.
There are better and more compatible ways how to extend the admittedly primitive exec memory allocator, but this particular idea is not a good one as far as compatibility is concerned.