Art Department Pro supported it ad well. Only paint program with direct support, though, was Opalpaint IIRC. but it was far better than the paint program for the Video Toaster which was basically DigiPaint which, and again this is coming from memory, painted in Amiga HAM mode and 'rendered' to the Video Toaster for final display so what you painted on was not necessarily fully WYSIWYG but an approximation. This board is more like the DCTV and HAM-E boards for the Amiga than 'real' graphics cards that went in the Zorro II and III slots. If I know how they worked, it was to encode the information in the video stream being sent through the video port (or slot in the case of Opalvision) and the card would decode that to create the proper display with more colors than the Amiga could produce. This is why when you view DCTV programs without the DCTV you see garbled screens where you can vaguely make out the user interface elements. Video port sends the data at video speed, which in my understanding was slower than the proper expansion slots. Advantages to HAM-E, DCTV and Opalvision is that they added more capabilities to Amiga video much more cheaply then full video cards, were standard TV video so they could integrate into the same broadcast and video equipment that the Amiga natively could, and did not require a separate and more expensive VGA monitor and a scandoubler to pull the Amiga video over to the RTG VGA monitor like the Picasso IV and Cybervision 64/3D does. Another 'advantage' of Opalvision would have been if the Video Processor was ever released. You can see on the board the socket for the Roaster chip and headers for connecting the Framebuffer RAM board and other parts of the Video Processor which would have expanded the Opalvision into a much more capable Video Toaster With all the CG, switching, chromakey and genlock capabilities of that board. Unfortunately this was never released and is one of the most famous pieces of Amiga Vaporware. It seems to me it was pretty far along development and is one of the real tragic stories of Amiga 3rd party development and some strange/bad business decisions. I have one so it did exist, even has ready for retail packaging. Have not connected it to my Opalvision yet to see if any of it works. This will be an episode of our TheGuruMeditation.org youtube channel for sure one day. That all said, I don't see a reason it would not work with the GVP Soectrum since I don't think that board pulls Amiga video at all. It will display what you tell it to using the Picasso 96 or Cybergraphx drivers. Opalvision should display anything being sent using the standard Amiga graphics modes including its own software. Only issue you might have is if you use Mode promotion which might try to grab the Amiga screens to 'upgrade' them to the RTG screenmodes.