It should be possible to bake the Amiga chipset and possibly even other chipsets into the ASIC, although a small FPGA for a chipset would be more flexible.
Maybe it makes sense to sum up the difference:
CPU
in FPGA ~ 600 Mhz 68020 Speed
in Very Good FPGA ~ 1200 Mhz 68020 Speed
+ needed investment to develop an FPGA system is low - some hundred to maybe thousand $ to get prototype
+ Bugs can be fixed in the field
CPU
in low end ASIC ~ 1000 MHz 68020 Speed
in high end ASIC ~ 5000 MHz 68020 Speed
- needed investment is huge for high end Asic the price for prototype can be in range of $200,000
- if there is a bug then the ASIC can not be fixed.
- To fix a bug again $100,000 need to be invested.
GFX Chipset
If you do the chipset well then you can get with todays entry level FPGA already super performance.
16bit CD quality audio is no problem.
FULL HD video output is no problem, 24bit truecolor is no problem,
If you do it right then having 100 times DMA performance compared to AGA is no problem with todays entry level FPGAs.
an ASIC could again improve over this.
But would have huge cost and huge risk.
I'm personally happy with FULL HD - I do not need 4K display ...
In regards of the chipset I would certainly prefer to use an FPGA to keep the risk and investments lower and to have the possibility to improve the chipset if we want to.