There used to be a "differential" SCSI flavor with an extended reach and higher reliability in comparison to single ended (SE), the then standard. It was in limited use in datacenters and for special purposes.
When Ultra2 (U2W) emerged it introduced low voltage differential (LVD) to allow the higher frequencies required. The old differential mode was renamed to high voltage differential (HVD).
The point is, HVD isn't and can't be compatible with SE. Devices may very likely be damaged when connected to one another. There are converters/bridges to adapt the signals but they're extremely costly.
LVD devices on the other hand are predominantly compatible with SE (LVD/SE), with the SE mode limiting the bus to Ultra speed (20 MB/s for narrow, 40 MB/s for wide). Even if an LVD device at hand isn't compatible with SE nothing will smoke.