Someone who was developing the AROS 68k ROM (I forget who) once told me he accidentally made the RAM: disk bootable once and it booted it. You can also boot from RAD disk (I tried this once, I effectively net booted using a boot floppy to pull an image of my workbench partition off the network and unpack it into RAD). So yes it is possible with only small changes, since a device doesn't need to correspond to a physical drive to be bootable.
All you need is a bootable disk with LoadWB on it to get a basic workbench, which is only a few kb. I suggested the idea of a ROM disk once. It would be interesting to be able to go straight to workbench from the boot menu, and could be very useful. Especially if there were room in ROM for such things as AmiTCP.