@that_punk_guy:
I have tried the mouse-theory now. Before, when using AGA I used Euro72 (640x400@70Hz), so I created an identical mode for the graphic-card and set up two monitors to the Amiga - one for the graphic-card and one for the AGA. When comparing the mouse movement between those two screens the movement on the graphic-card screen is still sluggish and on the AGA-screen it moves smooooth as ice :-/.
@lempkee:
Do you know what configurations any of these sluggish-move-movement-impaired-relatives of mine

were using?
@Karlos:
Tried a 60Hz mode, but the same sluggish feeling was there. Got curious if it synced with the 50Hz mains or something (a PAL Amiga), but I had some problems getting a 50Hz mode to work so I tried a 100Hz mode and the mouse felt more synced than ever, though still sluggish compared to when using AGA.
/Patrik