Denny Atkin wrote a book with that title back in 1993. It was filled with ways to live with flicker, how to reduce disk swaps, methods keeping commodore's original system files separate from those added by installers, hard drive organization, etc. There were hundreds of excellent, common sense strategies on every Amiga topic.
Seventeen years later, I'm curious what strategies other ppl have come up with. If lots of ppl contribute, this could grow into an incredible resource. For S & Gs, here are a couple of mine:
1 create a Vault: a place to keep keyfiles, your dopus config, years of bookmarks, or anything unique to a system that couldn't be reloaded in the event of a HD crash. It doesn't have to be big and that would make it easy to back up and have multiple copies.
2 To extend the life of my floppy drives, I've reversed the direction of flow of my cooling fan and put a cleanable filter on the intake side. Dust is no longer drawn into the mouth of the drive. This may not be for everyone, especially hot running systems.
3 Installation scripts usually look for a volume named Work:. If you're particular about the organization of your applications, don't name a partition Work.