Sort of. An old version of AmiGenerator was 060 compatible, but I got about 1.5 SPF (not FPS) on my Blizzard1260/50.
That's the only one I'm aware of. Too bad someone hasn't written an emulator that uses the Amiga's native 680x0 as opposed to re-implementing it. There'd probably be quite a few problems on the higher-level chips, due to instruction changes, though - Just how old Amiga 68000 games don't work well on newer machines. Could probably be corrected in a WHDLoad style, but might cost some speed.