I'm not sure if I care for them using both Reaction and MUI. I wish they would choose one. I have a feeling they only included MUI to support IBrowse, which by the way is an OEM. I hope one is eventually chosen exclusively in favor of the other or cleanly unified somehow in AOS5.
Speaking of IBrowse, this is another key point I hope is resolved soon. It needs to be dumped in favor of a more modern browser (like Mozilla) or bought from the current owner and put under heavy development to bring it up to date. I'd like the see the latter for nostalgic reasons, but unfortunately unless OS4 is a smash hit, I don't see where they could get the money. Mozilla is the obvious choice. Put one or two paid developers/magagers on it, open up a CVS site and let the rest of the community help out. I think Voyager got snubbed because of the MOS support they are including. It's a shame. With a little work, V could be a excellent modern built-in browser.
I'm a little worried about what they did with DOS pattern matching. I thought it was just short of *nix regular expressions without being too *nix-y, which is what I fear they have turned it into. I suppose this isn't THAT bad, but the old pattern matching was so elegant.
In all, I'm very happy with many of the features and I'm excited about the direction Amiga is headed. I'm hoping the weaker points are due to growing pains and will be worked out to make OS5 a serious contender in the industry.