Well, I use my Amigas for the internet (MiamiDx, IBrowse, YAM, AmIRC, ATC, Jabberwocky).
I program them in assembler, C, and E.
I sometimes write music in AHX or Protracker.
When I need to do some graphics, I use Perfect Paint, Personal Paint, and Photogenics.
For audio processing, I use SoundFX which came with my repulse card.
I also play a few games like Stunt Car Racer, Archer Macleans Pool, and Robocod.
I just really enjoy using my Amigas.
Edit: Oh yeah... I also use my Amiga to take pictures off of my digital camera using my Algor and poseidon.
I can't wait to get my hands on OS4 :-)