@moto
I had the same question. It was explained, and I did a little experiment to understand why.
Take two bits of paper and draw a female connector on each and number the end pins (1,2,43,44). Now, get those two female connectors to line up correctly. :-D
To answer your other question, yes you can blow stuff up if you hook the cable up wrong. I blew out a buffered IDEfix adapter hooking it up wrong on my A1200.