Unfortunately most Agnus chips have exactly the same PLCC packaging but they have a widely different electrical pinout.
Really?? Which ones are these, so we can look out for them? It would be a shame to accidentally fry one. All I've encountered have been pin compatible, but admittedly, I haven't gone looking for trouble, either. ;-)
To make them usable in earlier 512k Amiga's you have to do some work, add a capacitor, cut a track, change a jumper.
Actually, they are USABLE as a direct drop-in replacement in an A500. No mods needed. And they provide boot-time PAL/NTSC switching without mods (rev 5 and earlier A500s won't do that otherwise). If you want to enable the extra 512k CHIP RAM, then yes, thats how to do it.