OS4 will have built-in emulation for running code for the old 68k line of CPUs on the PPC based A1 and accelerator cards. The problem is that many older games relied on specialised parts of the Amiga's hardware, such as the Copper, and the built-in emulation won't handle this (it's designed for speed, not features). Of course, there's nothing to stop someone porting UAE to OS4; it might seem crazy at first, but UAE has full chipset emulation. Untill then, a lot of games won't work (probably the vast majority of the famous "classic" games).
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Of course, UAE runs on Linux and that runs on the A1.