Amithlon runs actually everything written for 68k in a system-conform way. It`s an emulator, like WinUAE, but it is much faster, and allows direct PCI bus handling through it`s powerpci.library and openpci.library.
This means you can use video gards, sound cards, LAN contrlrs, and USB devies as if you had an PCI-expanded amiga and those cards fitted inside it.
And the whole emulation is MUCH MUCH faster than WinUAE because the emulator is actually the only task that is ran in such a PC - it behaves close to a stand-alone OS.