I can't think of a reason why it would not be possible. It would, however, be a lot of work. Porting a driver would be half the job - RTG drivers would also have to be written to allow you to actually display anything. And if you already have a Mediator to get the USB ports, then you have access to PCI graphics cards anyway, which are not only neater as they are internal, but would perform bettern than USB video cards anyway.
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moto