Here's an idea that'll never be built, but I thought I'd share it anyway... The Ultimate Amiga Upgrade or UAU (pronounced wow).
Designed with the A4000D in mind, a single "fatherboard" overlayed on top of the motherboard... Plugging into the CPU slot, the daughtercard slot, perhaps even the ROM sockets.
The idea is to create a whole new high-speed local bus for the CPU to directly access PCI expansion, ZorroII/III, USB, dual channel ATAPI interface, scan doubler/flicker fixer, 16550 UARTs and whatever else one can think of to modernize an A4000D.
All this connected directly to the processors (68060 AND 604e) and memory. OR perhaps a G4/G5 processor to run OS4.
Obviously, this would require a new tower case to house it all, but it'd be one HELL of an upgrade!