alx: that linki of yours gives 404 error..
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Mouse: some of old Amiga softwares should run Ok.. I have no way of testing them (mainly due lackof AmigaOne and OS4) but based on my own experience with Pegasos+MorphOS I'd say there will be interestign times on sorting out which one works and which ones dont..
Of existing and still developed programs.. At least Pagestream and AudioEvolution are going to have OS4 native versions. There have been talks of Real3D port, but you'll better ask from Lempkee about it, IIRC he knows person doing the port.
On games.. Besides Hyperion (whom are busy with OS4, Linux and Uboot atm) I can't remeber hearing a lot lately. There have been announcements some time ago (year/two) but I have not seen any real progress..