Do you....
a) Shoot them.
b) Call 999 and pray the cops come faster than Pizza Hut.
c) Get raped and die.
Hint: My wife answers "a".
Yeah, like you have a wife :-P If you do, she must be one very patient woman!
Anyway, you said earlier that your guns are totally locked down and secure and so on.
How the hell are you supposed to crack them open, load them and fire them at your assailants in any situation where they break in without disturbing you immediately?
Unless your guns are easy for you to get hold of and load in an extremely short space of time I fail to see how option "a" could be enacted except in the case the guys are stood there making a massive disturbance for however long before getting in. Let's face it, that's not exactly what happens in the majority of cases.
Of course, if your guns are easy to get hold of quickly, they are that much easier to steal too.
You realistically can't have it both ways. You can have them properly secured or you can have them ready to use in a genuine emergency.