Nothing, the more the better. Ideally any 68k OS should run well on a 68080, it's too late to adapt the software to the hardware, but with FPGA you can adapt the hardware to the software. I would love to run *nix type OSes (old classics like NeXTStep, Apple UX, SunOS, Domain/OS, as well as modern Linux and NetBSD) on 68080 too, but as it is currently a 68EC080, missing the essential MMU, this is not possible.