European cards are based on centimeters and therefore won't work with American-style cardstock.
It should be possible to make a template with minimal difficulty since you know the measurements relative to an 8 1/2" by 11" sheet. Just make a grid with horizontal granularity of 4" and vertical granularity of 2". Use snap to grid when you do the layout and then use cut-and-paste to copy the first card to the additional spaces.
Don't ask me for the specific menus for these options since I'm thinking of how it was done on PageStream 2.2 before the source-base was redone in C++. I do have PageStream 4 but don't use it much due to problems I've had with my MicroA1-c.