Whenever I want to do some animation, or sequence some music, it's much easier to do these things with PPaint and OctaMED Soundstudio than anything on the PC (although for recording organic audio projects I use Cakewalk.) (Edit: or my trusty TEAC 4-track ;-))
But my main machine is an x86 box. As people have pointed out, they can't be beaten on price. For about £500 I got an Athlon system that runs apps nice and quick, (and in terms of 3D performance it pisses on the current video consoles from a great height.) And AROS just flies :-D