You can, you just need to leverage the card's 3D features rather than doing it in software.
Yep. I get ~16 fps with GLQuake/BlitzQuake "timedemo demo1" the 2nd time (textures cached) at 640x400x16 with CSMK3 68060@75MHz, Mediator with Voodoo4 and tweaked Warp3D drivers. The 68060 can push descent frame rates even with a slow Mediator bus but the 68k Warp3D drivers are very poorly optimized. No, the 3D card does NOT do all the work! GLQuake/BlitzQuake is fairly well optimized, especially considering it's mostly C and uses the FPU.