DMA mode significantly decreased CPU load on my system. I emailed E3B about this, and Michael said I may be experiencing something with the Buster 11 and my PIV. I'll work on this later this weekend.
I have a similar setup, with an MKII and PIV. I had DMA problems (read errors, sometimes a reboot during transfers) that were cured when I swapped the bridge chips on my PIV with
the latest version from another card. I haven't upgraded the Flicker Fixer chip yet.
Rarely, I still encounter a read error, but it's always recoverable, and only with the MKII overclocked. I imagine this is a timing issue resulting from the overclocking.