as you list it as 52x then its gotta be IDE right?
Then its normal stuff, check that its Master if its the only one on the chain, if it shares the cable make sure they are both not set to master or both to slave.
As its not taking down the whole system Im going to say its not that your cable is running close to some chips or anything like that.
Other than that its a matter of reinstalling the CDFS software I guess (although it cant go to wrong)
Good luck
