ATM Prometheus doesn't work with DMA cards so that pretty much restricts you to RTL8029 & gfx card (well, perhaps some audio card with ability to work without DMA like Terratec128i works on OS4 but I don't know if anybody has tested it). It's quite fast, the only problems you may have is fitting it inside the case. There are 3-pci adapters that could help you to fit it inside normal cases.
Voodoo3 works nicely, it's specially noticeable if you plan to use high resolutions. I also tested Ratte's Radeon9250 OpenPCI driver and worked correctly too.
There's a firmware update and although it's taking some time I guess it will worth it.