For a while I was trying to use my SAM440ep-mini as my main computer, but was forced to guit (for a while) because I found myself setting it up more than getting things done.
Now with my new job and some family matters I have very little hobby time on my hands. I hope I manage to change the situation soonish.
Then I will set up AEROS+MOS+AOS4+AOS3 systems to run in parallel and with that combo I'm pretty sure I can happily use Amigalikes as my main system(s). (then bye bye Linux desktops, go where Windows and OSX went already, the dumbster)
If you lack time it's better you focus on a single machine, otherwise you'll spend more time configuring and installing stuff instead of using your favourite OS.
My main machine is a G4 Mac Mini running MorphOS although I use others from time to time. I mostly use it to browse the web, email, chat, code, use it to play audio/videos and test amiga stuff.