If I remember correctly if at first the device is not detected, you can run the software as many times you want, it should edit/overwrite the user start-up for you.
the only problem I had with this software is it does not show list of audio files when using a SCSI DVD rom drive, but works fine with a normal drive.
Software needs an update as MasterISO needs it to work correctly. As far as I know only SCSI DVD drive is affected.
It can still play audio files, but list of tracks is not listed and this is where MasterISO fails, as tracks are not listed and audio files can't be edited from MasterISO.