Set you accelerator's memory jumpers for all memory mapped high.
Set your VA2000 for the preferred size for your machine (I have read that 2MB is preferred in Zorro II situations, not for speed, but to leave space for other memory allocations in the 8MB Zorro II expansion (8MB) space.)
Set the Supra to 6MB mode if the above is true, or 4MB if you are advised otherwise.
Make sure you are using some kickstart remap tool (GVPCPUCTRL - if the CPU is an EC model) or the OS CPU FastROM command (if the CPU has an MMU), and that both caches are on (CPU Cache). I don't know if the VA2000 is preferred to have the data cache turned on after the drivers load for it - check the docs.
As for being 'picky', know the Amiga memory architecture and where your product's memory is being placed. In most cases, placing all Accelerator 32-bit RAM up high is best, unless you have a need for some in 16-bit DMA space. 16-bit RAM,l like on the Supra, is used later, after all 32-bit FastRAM is used.