Just a quick note.. Get a quiet fan and have it point out of the chassis! The fan should not blow it's hot air on the cards or anything else.
The fan should draw thru the front and distribute around the cards cooling them and add the PS heat before exit...
If you look at the 4000 case design, it does not pull any air through the front,it can't because for the most part the front bezel seals it all off(well not perfectly,but pretty well)..
Air enters the back of the case through the holes near the slot brackets,moves over the cards towards the front, goes around the zorro slot board at the front, and over the accelerator and into the psu and out the back of it. A little if pulled over the HD's but its almost a dead spot for air where the HD's are.
Some people add slot fans between zorro boards but it can actually fight the psu fan and make cooling worse.
One way to improve cooling is use the slot covers that are perforated with holes.It gives more area for air to come in. This works if your slots are not all full of cards.
The Noctua nf-r8 fluid bearing fan i mentioned earlier gains 5 more cfm than the stock amiga fan and is very quiet. They seem to last forever when kept clean.