One final point to note. When you enable Mix mode, the note range for sample playback is increased by 2 octaves in the low register. That is to say, the pitch you'd get from C-3 in 4 channel mode is now 2 octaves lower. To get the same pitch, you need to use note C-5.
You'll encounter this problem if you load an old 4 channel mod and enable mix mode and try to play it. To correct it, you need to use the Edit -> Transpose option which opens the transpose window. You'd need to globally increase all notes by 2 octaves.
And here in lies the answer. Everything is starting to make more sense now, though I'm having issues still.
The tempo is all messed up when I put things into 64Ch Mode, which is easy to fix, though I did want to point it out.
As for this Transpose option. It looks like I have to select the Sample I want, then click source and then destination, then octave up twice in order to make it work. Sadly this seems to work for some samples, others still sound like crap.
None the less I'm on the right track and will have another stab at 16-bit samples here in a bit.
Oh, and why is it that OctaMED SS does not use standard BPM mesures, but instead has that strange tempo interface with the 3 lines? How would I ever sync this up to somthing that is running at say 200BPM, and how would I know the diff between 4 channel mode's timing and that of 64 Mix Mode?