Would be quite easy under Linux with X and sandboxes or under Windows with Citrix and app isolation. You could also do it with Amithlon running on a VM. (Hosting virtual guest OSes running UAE would be overkill and harder to manage, IMHO, but I'm sure others will disagree.) In any case, you would have to license Amiga OS for such use.
Once you have it, what would you do with it?