Yeah, I'd forgotten about the Shres modes in AGA, I was thinking only of the ECS chipset. Which would be about 752pixels/line x ~15625 x 12 bit = 141mbit/sec. And I guess you're right to consider the actual horizontal frequency- so as not to overrun the maximum usb speed, I hadn't thought of that.
As for getting the video data onto USB2, I thought to tap into the Amiga directly and pick up the digital pixel data as it comes out of Denise.. no need to mess with A/D conversion.