So much depends on exactly what your running, which machine, OS, etc.
I used to run Super72 with 3.1 and 3.5 for a killer 800x600 when tweaked with a utility called MonEd. This was on an A1200 to a CBM 1942 monitor, but I also used it with an NEC 3D for while.
Pay close attention to the part about MonEd. Without it, the Super72 was a mess.