Obviously those two screws on the mouse port are not original. So someone had the motherboard out for some reason. I have seen the occasional motherboard that was sensitive to those screws.... tighten them down, and the mouse port fails, back off a bit and it's OK. It's been a while so I don't remember what the failure was... Incidentally, the fuse mentioned earlier in the thread has nothing to do with the buttons, only the motion.