It looks interesting, but a little sparse. You'd need to build a board (or boards) with the CPU, RAM, PIC, and all the I/O stuff. I had something like that in mind, using the Schmartboard prototyping boards - they make it easier to hand-solder fine pitch smt parts. This board would essentially be the FPGA and power boards of that idea.
But, if the gentleman in another thread succeeds with his project, a better idea would be to use one of the larger boards - with RAM and a larger FPGA holding a soft 68K. Some of those boards are only $50 more then this one. XESS has one with a 1 million gate Spartan 3, RAM, VGA, and one mouse/keyboard port for $199. Add a daughter board with the other mouse port, joysticks, and serial port plus upgrade the existing VGA to 4 bits/color instead of 3, and you you're good to go.