Nice idea, the Amiga Hardware on a card, with WinUAE altered to use it, whilst still running 68k emulation itself. Of course you would need to route all the output back into the host computer (audio, graphics, etc) to integrate into its output - unless the card had its own graphics and audio I/Os.
An alternative idea in the opposite direction is to extend the MiniMig hardware implementation to add some chunky graphics modes, and write a Picasso96 driver that uses them. It would only be useful for Workbench, etc, but if you could have some graphics modes like 1280x720, 1920x1080 it would be neat on a modern TV. Probably would need a MiniMig implementation with SDRAM rather than SRAM, to use the extra capacity, or be stuck with 4 colour hi-res modes or divisors of that mode (640x360, 960x540). Also the 68k might struggle to manage that on its own...