Let's look at Nintendo, shall we? They tried to play the hardware game (N64, GameCube) for ten years, and lost. Then they came out with...
Wii. Not a great machine by the paper specs, but it changes the way you think about games by immersing you on a different level. I have only played it a couple of times and the most banal of games (Bowling, tennis, etc.) seemed like new experiences. This is the kind of thing that changes markets. That is what Amiga needs. A change in market focus.
If Amiga can make some shift in gameplay happen, great! But they also need good developers. The coolest OS and the slickest hardware are nothing without developers. Developers like SDK's. They don't like banging the hardware from the get-go because it's HARD. There is no SDK for Amiga, at least not an easily accessible one.
I agree with the idea of going for the creative market. Build the media features of the OS; make it physically able to connect to ANYTHING multimedia related; make it sort of a god box for media creation. The chips to do this are not so expensive anymore.
Oh, and make it able to boot windows and OSX. (in other words, to whomever wins the suit, PORT THE FRIGGIN OS TO x86 already!!!) If people can boot the Amiga side quicker than the Windows or Mac side, they will want to use that instead, for simple tasks like checking e-mail and google mapping. People don't think about how powerful the OS is, they just want to get working quicker. As a help desk tech I constantly heard people ask "when are we gonna get faster computers? This one takes ten minutes to boot in the morning!" AmigaOS can shine here, giving people faster access to the tools they need.