NOROMUPDATE option only tells SetPatch not to load the extra BB2 modules found within the file "AmigaOS ROM Update" that resides under DEVS folder.
The file contains the following modules:
Apparently one or more modules is messing with your system.
If you don't mind having the newer versions of these modules you're gonna be fine with NOROMUPDATE option.
If you want to check though which module is giving you a hard time you can use the option SKIPROMMODULES with the module (or modules seperated with a comma) that you want to exclude loading.
For example:
SetPatch SKIPROMMODULES "scsi.device" QUIET
...will load all the BB2 modules but exclude scsi.device.