Well I've done a little research and from what I understand as long as a program is not trying to access the amigas custom chips it should run on a Sam under os 4.1. So for example old games will not run but a word processors should work or other standard apps. I have not received my Sam yet, it is supposed to be here this week so I'm certainly no authority. As far as software that has been tested I guess OS4 depot is apparently the best resource and aminet of course. I have personally found it a bit difficult gaining info on OS4 and Sam. I don't know if it has to do with the ongoing legal battle or what but I'm sure that doesn't help matters. I actually made a suggestion awhile back to have a section of Amiga.org devoted to OS4 and Sam etc... but it seems to have fallen on deaf ears.