DriveSpeed reports the following figures for both FFS & SFS HDs...
Using FastATA MKIII Buffered interface...
5,487,263 Bytes Per Second
Using 4xEIDE Buffered interface...
2,547,512 Bytes Per Second
You can run two 2.5" HDs on the Amigas motherboard IDE connector but you have to keep the cables to about 2 to 3 cm at most (but I don't recommend it)...

Finding the FastATA MKIII or the 4xEDIE can be tricky though, just bought another 4xEIDE board on eBay last week cost £27.50 and a FastATA MKII sold for £47...
