I've tried PFS in the past but I much prefer to use SmartFileSystem myself. I'ts very easy to use and set up, no problems with block sizes or such like. Been using it for about 4 to 5 years now and have never lossed a single bit of data.
Best of all using SFS2 you can have up to 1 Terabyte sized partitions and no limit on file lengths, which is needed if you want to store backup ISO images of your DVDs which can be up to 8Gb in size.
