I'd strongly disagree on going Intel for the same reasons I gave against PowerPC: Vendor Lock-in. Intel you're tied to Intel, period, the end. Intel doesn't support your efforts, too bad.
I would instead look to one of the licenseable architectures, whereby if a vendor does not deliver, well, you control your own destiny and can change fabs, vandors, etc with minimal issues. ARM, MIPS and SPARC all qualify. ARM is expensive to license, but quite popular. MIPS is less expensive to license, and with the new Chinese Loongson CPU's shipping are making a strong comeback. SPARC tho, least expensive to license, and with the strongest reputation among them all. Hell, I made a SPARC based mp3 player for myself a few years back. Tried to do that with Intel anytime lately?
What would the Amiga offer? Look at the newest trends in computing, for lighter weight, faster operating machines weither they have the CPU power or not. Netbooks, tablets, e-books, cell phones, that is the target for a new Amiga. The Amiga's instant-on capability, ideal for this market. Desktops and workstations would be mainly for support of the real market, the portables. That would be my ideal.
So, what would I do? Make a SPARC based System on Chip for the netbooks, with a HT bus for expanding into a full fledged desktop and workstation CPU. PowerPC is a dead end. ARM and MIPS are too expensive. Intel is proprietory. AMD is not mobile. VIA cannot handle the desktop.
I have plans for a MiniMig based PDA, to demonstrate this. Plans I likely will never finish because I don't think anyone here cares about playing to the Amiga's strengths, only in focusing on some pipe dream. There is nothing stopping us from reaching our dream of a new Amiga save ourselves.