Slightly off-topic, but one thing I find infuriating about Vista is how sometimes the hard disk will be getting completely thrashed, yet nothing shows up in Task Manager suggesting that any particular process is up to much. Yes, I realise that high disk IO = high processor usage went out when DMA came along, but still, normally I would expect to be able to pick out a process that was doing that much disk work.
You can. Press ctrl-alt-del, go to performance, then resource monitor and click the disk tab. As previously mentioned it's probably the indexing service doing this, the vista indexer can be a bit flaky.